Individuals on the frontlines of dissemination and implementation (D&I) science will convene this December to investigate real-time integration of evidence-based interventions, understand their limitations, and identify unintended consequences in this rapidly shifting information landscape. The 19th Annual D&I Science Conference will explore the theme “Elevating the Science of Dissemination: Leveraging Tools to Improve Clinical, Community, and Public Health Practice” through a combination of plenaries, concurrent sessions, and posters that will present research findings and set the field up for the next decade.